Peptides on the skin of African clawed frog protect from bacterial infection by having a semiselective binding nature to bacterial pathogen cells affording each peptide the ability to bind a variety of pathogens.
"AMPs [antimicrobial peptides] appear in multiple niches in nature including the skin of higher organisms and the extracellular milieu of bacteria as the primary line of defense against bacteria and fungi. AMPs are much more stable than typical globular proteins—explaining how they can be continually exposed to the natural environment—and are exceptionally efficient at fending off bacterial infection. Indeed, some cationic antimicrobial peptides have shown activity toward pathogenic bacteria under harsh environmental conditions such as thermal (boiling/autoclaving) and chemical denaturants." (Mannoor et al. 2010:19207)
Learn more about this functional adaptation.
- Mannoor MS; Zhang S; Link AJ; McAlpine MC. 2010. Electrical detection of pathogenic bacteria via immobilized antimicrobial peptides. PNAS. 107(45): 19207–19212.
- Emery C. 2010. New sensor derived from frogs may help fight bacteria and save wildlife. EurekAlert [Internet], Accessed 19-Oct-2010.
- Bowman HG. 1995. Peptide antibiotics and their role in innate immunity. Annual Review of Immunology. 13: 61-92.
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