Peptide defensin fights pathogens: animals
Defensins are naturally produced peptides that inhibit pathogen growth and degrade pathogen toxins by binding to the pathogens
“In addition to their bacterial membrane permeabilizing capacity, defensins have been shown to neutralize bacterial invasion by directly binding to bacterial toxins….Similar properties have been described for retrocyclins, a class of circular defensins found in non-human primates, which were shown to bind to the anthrax lethal factor with high affinity .” (de Leeuw and Lu 2007:69)
Learn more about this functional adaptation.
- de Leeuw, E.; Lu, W. 2007. Human defensins: turning defense into offense?. Infectious Disorders Drug Targets. 7(1): 67-70.
- Zou, G.; De Leeuw, E.; Li, C.; Pazgier, M.; Li, C.; Zeng, P.; Lu, W-Y.; Lubkowski, J.; Lu, W. 2007. Toward understanding the cationicity of defensins. The Journal of Biological Chemistry. 282(27): 19653-19665.