Males 91-103 mm, females 111-119 mm. The dorsum is dark green and the belly varies from white to yellow-white or cream. There are sparse white spots with dark frames on the lower lips, chest and front legs, and these are more dense on the flanks and hind legs. Fingers are transparent brown with large green adhesive discs. A prominent gland extends from behind the eye over the tympanum. The iris is dark gray.
Similar species: Phyllomedusa tarsius differs by having a red-orange iris with black reticulations, and by having brown first and second fingers with white tips. Phyllomedusa vaillanti differs by having purple coloration on the sides and belly, adhesive discs on the fingers that are orange or dark purple, and a silvery-gray iris.