Mycobacterium bovis is a slow-growing (16 to 20 hour generation time), aerobic bacterium and the causative agent of tuberculosis in cattle (known as bovine TB). Related to M. tuberculosis—the bacterium which causes tuberculosis in humans—M. bovis can also jump the species barrier and cause tuberculosis in humans.
It has been estimated that, during the first half of the 20th century, M. bovis was responsible for more losses among farm animals than all other infectious diseases combined. Infection occurs if the bacterium is ingested.
M. bovis is usually transmitted to humans via infected milk, although it can also spread via aerosol droplets. Actual infections in humans are rare, mostly due to pasteurisation killing any bacteria in infected milk; as well, cattle are randomly tested for the disease and immediately culled if infected but can still be used for human consumption. However, in areas of the developing world where pasteurisation is not routine, M. bovis is a relatively common cause of human tuberculosis.
Epidemiology and control
In New Zealand, the common brushtail possum is the main vector for the spread of M. bovis. The disease now endemic in possums across approximately 38 per cent of New Zealand (known as ‘vector risk areas’). In these areas, nearly 70 per cent of new herd infections can be traced back to possums or ferrets. The Biosecurity Act 1993, which established a National Pest Management Strategy, is the legislation behind control of the disease in New Zealand. The Animal Health Board (AHB) operates a nationwide programme of cattle testing and possum control with the goal of eradicating M. bovis from wild vector species across 2.5 million hectares – or one quarter – of New Zealand’s at-risk areas by 2026 and, eventually, eradicating the disease entirely. 
The TBfree New Zealand programme is regarded as "world-leading" . It has successfully reduced cattle and deer herd infection rates from more than 1700 in 1994 to fewer than 100 herds in July 2011. Much of this success can be attributed to sustained possum control reducing cross-infection and breaking the disease cycle. For example, at Hohotaka, in New Zealand's central North Island, control work from 1988 to 1994 achieved a sustained mean reduction of 87.5% in the density of Tb‐infected possums. As expected, annual Tb incidence in local cattle herds consequently declined by a similar amount (83.4%).
From 1979 - 1984, possum control was stopped due to lack of funding. In spite of regular and frequent TB testing of cattle herds, the number of infected herds snowballed and continued to increase until 1994.  The area of New Zealand where there were TB wild animals expanded from about 10 to 40 per cent.
That possums are such effective transmitters of TB appears to be facilitated by their behaviour once they succumb to the disease. Terminally ill TB possums will show increasingly erratic behaviour, such as venturing out during the daytime to get enough food to eat, and seeking out buildings in which to keep warm. As a consequence they may wander on to paddocks, where they naturally attract the attention of inquisitive cattle and deer. This behaviour has been captured on video. 
In the 1930s, 40% of cows in the UK were infected with M. bovis and there were 50,000 new cases of human M. bovis infection every year. According to DEFRA and the Health Protection Agency, the risk to people contracting TB from cattle in Great Britain today is very low. The HPA has said that three quarters of the 440 human cases reported to the HPA between 1994 and 2006 were aged 50 years and above and only 44 cases (16%) were known to be non-UK born.
Badgers (Meles meles) were first identified as carriers of M. bovis 30 years ago, but it was the report of an independent review committee in 1997 which concluded that badgers made an important contribution to the spread of M. bovis between herds of cattle. This was the major cause of the current battle between animal conservationists (keen to save the badger) and farmers (keen to cull badgers, to reduce livestock losses). The Randomised Badger Culling Trial  (designed, overseen and analysed by the Independent Scientific Group on Cattle TB, or ISG ) was a large field trial of widescale (proactive) culling and localised reactive culling (in comparison with areas which received no badger culling). In their final report, the ISG concluded: "First, while badgers are clearly a source of cattle TB, careful evaluation of our own and others’ data indicates that badger culling can make no meaningful contribution to cattle TB control in Britain. Indeed, some policies under consideration are likely to make matters worse rather than better. Second, weaknesses in cattle testing regimes mean that cattle themselves contribute significantly to the persistence and spread of disease in all areas where TB occurs, and in some parts of Britain are likely to be the main source of infection. Scientific findings indicate that the rising incidence of disease can be reversed, and geographical spread contained, by the rigid application of cattle-based control measures alone." .
On 26 July 2007, the Minister of State, Department for Environment, Food and Rural Affairs (Lord Rooker) said "My Lords, we welcome the Independent Scientific Group’s final report, which further improves the evidence base. We are carefully considering the issues that the report raises, and will continue to work with industry, government advisers and scientific experts in reaching policy decisions on these issues."
In the UK, many other mammals have been found to be infected with M. bovis, but the frequency of isolation is much less than cattle and badgers. The disease is found in cattle throughout the globe, but some countries have been able to reduce or limit the incidence of the disease through process of 'test and cull' of the cattle stock. Most of Europe and several Caribbean countries (including Cuba) are virtually free of M. bovis. Australia is officially free of the disease since the successful BTEC program, but residual infections might exist in feral water buffalo in isolated parts of the Northern Territory. In the United States, there is endemic M. bovis in white-tailed deer in the northeastern portion of the state of Michigan and in northern Minnesota, and sporadic import of the disease from Mexico. In Canada, there are affected wild elk and white-tailed deer in and around Riding Mountain National Park in Manitoba. "To improve control and eliminate bovine TB, the Canadian Food Inspection Agency (CFIA) has split Manitoba into two management areas: [The] Riding Mountain TB eradication area (RMEA), the area where the disease has been found [and] the Manitoba TB Eradication Area (MTEA), the rest of the province outside RMEA where the disease has not been found." The disease has also been found in wild buffalo in South Africa and brush-tailed possums in New Zealand.
In a 2010 opinion piece in Trends in Microbiology, Paul and David Torgerson argued that bovine tuberculosis is a negligible public health problem in the UK, providing milk is pasteurized. Bovine TB is very rarely spread by aerosol from cattle to humans. Therefore, the bovine tuberculosis control programme in the UK in its present form is a misallocation of resources and provides no benefit to society. Indeed there is even very little evidence of a positive cost benefit to the livestock industry, as few studies have been undertaken on the direct costs of bovine TB to animal production. Milk pasteurisation was the single public health intervention that prevented the transmisison of bovine TB to humans and there is no justification for the present test and cull policy in the UK. 
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